Research

 
 

Our synthetic organic research is focused on reactions involving free radical intermediates.  Much of the work involves the synthesis and use of designed nitroxides for both the preparation of specialized polymers for applications in nanotechnology, and as sensors via fluorescence quenching.  We are also engaged in the development of new synthetic methodologies.

 

α-H Nitroxides to Prepare Tailored Polymers for Applications in Nanotechnology

    • Stereochemistry of Prochiral Radicals coupling with Chiral Nitroxides

          (the genesis of TIPNO in  Nitroxide-Mediated “Living” Free Radical Polymerization)

      • Designed Nitroxides to Prepare Tailored Polymers for Applications in Nanotechnology

        Polymer Chain End Functionalization

        Bidirectional Initiators

        Cyclic Polymers

    • Designed Nitroxides for NMP in scCO2 (new collaboration with Fawaz Aldabbagh and

                         Carlos Elvira)

    • Non-migratory phthalate mimics


 

Unobtanium,

the most elusive of elements....

Nitroxides as Fluorescence Quenchers

    • Nitroxides + “Quantum Dots”

    • Detection of Urushiol from Poison Oak/Ivy/Sumac with Profluorescent Nitroxides

    • Photoinduced Nitroxide Quenching


 

Synthetic Methodology Development
	• Radical [n+1] Cyclizations with SO2	
	 • Acyl Radical Generation and Cyclizations	
	• Synthesis of N-Alkoxyamines 	Syn_Methodology.htmlResearch_files/NitO%E2%80%A2%20+%20CdSe%20QDs%20clip.cdxshapeimage_6_link_0